Conformationally restricted 3′-modified ABA analogs for controlling ABA receptors
نویسندگان
چکیده
منابع مشابه
Conformationally Restricted Fentanyl Analogs
Synthesis, analgesic activity and preliminary molecular modeling studies of the cisand trans-fused octahydro-l,2,3,4,4a,5,11,1 la-pyrido[3,4-c][1,5]benzoxazepines 8 and 9, the first rigid fentanyl analogs with a conformationally restricted 4-anilido group that retain antinociceptive properties, are reported. Fentanyl (1) is the prototype of the highly potent 4-anilidopiperidine class of synthet...
متن کاملStructural analogs of ABA reveal novel features of ABA perception and signaling in Arabidopsis.
Changes in gene expression produced by the application of (+)-abscisic acid (ABA) to Arabidopsis thaliana plants were compared with changes produced by the ABA structural analogs (-)-ABA, (+)-8'-acetylene ABA and (-)-2',3'-dihydroacetylenic abscisyl alcohol. The maximum expression of many rapidly (+)-ABA-induced genes occurred prior to peak hormone accumulation, suggesting negative feedback reg...
متن کاملAba+
We present ABA, a new approach to handling preferences in a well known structured argumentation formalism, Assumption-Based Argumentation (ABA). In ABA, preference information given over assumptions is incorporated directly into the attack relation, thus resulting in attack reversal. ABA conservatively extends ABA and exhibits various desirable features regarding relationship among argumentatio...
متن کاملA Novel Chemical Inhibitor of ABA Signaling Targets All ABA Receptors.
Abscisic acid (ABA), the most important stress-induced phytohormone, regulates seed dormancy, germination, plant senescence, and the abiotic stress response. ABA signaling is repressed by group A type 2C protein phosphatases (PP2Cs), and then ABA binds to its receptor of the ACTIN RESISTANCE1 (PYR1), PYR1-LIKE (PYL), and REGULATORY COMPONENTS OF ABA RECEPTORS (RCAR) family, which, in turn, inhi...
متن کاملConformationally restricted TRH analogs: a probe for the pyroglutamate region.
In principle, the development of the active analog approach to computer-assisted drug design can offer a unique opportunity for dramatically increasing the efficiency of designing new drug candidates by predicting the biologically active conformation of peptide ligands.1 But how do we know that such molecular modeling predictions are accurate, and can a specific set of chemical probes be develo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2015
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c4ob02662d